EndoRNA diagnostic test - endometriosis detection + medical consultation

For whom is the EndoRNA test intended?

EndoRNA test is worth performing in patients with suspected endometriosis to confirm the disease or in patients in whom you want to exclude it. The test allows you to significantly shorten the diagnostic pathway, which is associated with faster initiation of treatment if endometriosis is diagnosed.  

The package includes: 

• gynecologist's consultation with qualification and collection of material for the test; 
• EndoRNA qrt-PCR diagnostic test;
• gynecologist's consultation with discussion of test results (teleportation).

What is the test based on? 

The marker used in the EndoRNA test is the expression of the gene encoding the enzyme fucosyltransferase 4 (FUT4). The essence of the test is to evaluate the mRNA level of the FUT4 gene relative to the mRNA level of the GAPDH reference gene in endometrial tissues. The expression (mRNA) of FUT4 is significantly elevated in the endometrial cells of patients with endometriosis compared to the endometrium of healthy patients. The test is performed by quantitative RT-PCR.

The EndoRNA test is used to determine the presence of the disease, not the likelihood of the disease. 

How is the collection of material for the test carried out?

In order to perform the test, a sample of endometrium collected by aspiration biopsy is needed. The collection takes place in a gynecologist's office and takes only a few minutes. Importantly, the procedure is minimally invasive, causes only minor discomfort and in most cases does not require the administration of general anesthesia. After the collection, the patient can immediately return to daily activities. 

Interpretation of the test results

The waiting time for the result is 7-14 days.

• A positive test result indicates elevated expression of the FUT4 gene, which means a high probability of endometriosis.
• A negative test result indicates low expression of the FUT4 gene, ruling out endometriosis.

Note that, as with any other diagnostic test, a false negative result is possible. In the case of the EndoRNA test, false negative results can affect 6-11.8% of results.

You can receive treatment for endometriosis at Damian Medical Center. We perform laparoscopic endometriosis surgery, as well as endometriosis scar excision surgery.

What is endometriosis? 

Endometriosis is a gynecological disease characterized by the presence of tissues resembling endometrial structures outside the uterine cavity. It can cause very severe pain and problems getting pregnant.

Symptoms of endometriosis include: 

• heavy menstrual bleeding;
• abdominal pain - during menstruation or regardless of the phase of the menstrual cycle;
• pain in the lower back;
• pain during or after sexual intercourse;
• painful urination or bowel movements;
• discomforts related to the digestive system - nausea, constipation, diarrhea. 

Worth knowing: 

• According to the World Health Organization, endometriosis can affect up to 3 million women in Poland. Every year it is diagnosed in an increasing number of women. 
• Endometriosis is difficult to diagnose and treat. The average time to confirm a diagnosis of endometriosis is as long as 7-12 years. 
• Untreated endometriosis can lead to infertility.

Note: the material for the test will be collected during the visit to the gynecologist (after qualification). After purchase, call the hotline to schedule an appointment with a gynecologist as part of the package -  22 566 22 22.

Collection of material for the test must take place in the early secretory phase, that is, between the 14th and 21st day of the cycle (with a standard 28-day cycle).

The services included in the package can be used after 3 working days from the date of purchase. The validity of the package is 3 months.

Preparation for the test

• 4 days before the test is scheduled, you should not take any vaginal medications, use tampons or perform procedures involving vaginal lavage. 
• Your doctor may not qualify you for the test if you are in the wrong phase of your cycle or on hormone therapy. The material can be taken only 3 months after discontinuing hormonal medication.
• The test cannot be performed in pregnant women.
• The service is intended for adults. 

If you have any questions, feel free to contact us via the hotline: 22 566 22 22.

Why take the test?

• Sensitive and specific diagnostic method
• Simple procedure for collecting material for the test
• Acceleration of the moment of diagnosis - a chance to start treatment sooner