Panorama test: chromosomes 13, 18, 21, X and Y, triploidy, Di George syndrome

Panorama - prenatal test

The Panorama test is a non-invasive, safe, screening prenatal test.

The Panorama test helps determine the risk of common genetic defects caused by extra or missing chromosomes in the baby's DNA:

1. Down syndrome (trisomy 21)
2. Edwards syndrome (trisomy 18)
3. Patau syndrome (trisomy 13)
4. triploidy
5. sex chromosome abnormalities:

• Turner syndrome (monosomy X)
• Klinefelter syndrome (XXY)
• Jacobs syndrome (XYY)
• triple X syndrome (XXX).

Triploidy is a chromosomal abnormality very often leading to fetal demise, associated with severe birth defects and pre-eclampsia. Births are extremely rare.

The Panorama test can determine the risk of 22q11.2 deletion syndrome (DiGeorge syndrome) associated with serious health problems.

The Panorama test can be performed after the end of the 9th week of pregnancy until the day of delivery.

Before performing the Panorama test, it is necessary to perform an ultrasound focused on assessing fetal number and gestational age, so it is optimal to perform the Panorama test after the first prenatal ultrasound (11th-14th week of pregnancy).

In a small percentage of cases, it may not be possible to obtain enough information from a blood sample to determine an accurate result. In this case, it may be necessary to take a second blood sample. This happens more often with pregnancies in obese patients.

The Panorama test is intended for pregnant women, regardless of age, except in the case of:

• multiple pregnancies of more than 2 fetuses,
• necrosis of one of the twins,
• twins conceived with the help of a surrogate or egg donor,
• pregnancy after bone marrow transplantation,
• less than 6 months after a blood transfusion,
• before the end of the 9th week of pregnancy.

You may want to consider taking the Panorama test after consulting with your pregnancy doctor to make an informed decision.

Is the Panorama test the same as the PAPP-A test?

No. The Panorama test examines the fractions of fetal DNA present in the mother's blood, while the PAPP-A test is based on an assessment of the levels of PAPP-A protein, the free β-hCG subunit and the nuchal translucency image seen on ultrasound. The Panorama test can be the next step in fetal diagnosis when the risk in the Pappa test is between 1:100 and 1:1000.

Additional information

The Panorama test is a genetic, non-diagnostic test, that is, it does not determine the presence of a genetic disease in the baby, but assesses the risk of the disease. The test is based on testing the fraction of fetal DNA that is present in the mother's bloodstream. The blood sample taken is analyzed to see if there are genetic changes that could affect the baby's health.

The Panorama test is complementary to first trimester pregnancy screening, including ultrasound, which should be performed according to the recommendations of the Polish Gynecological Society.

Prenatal testing - why the Panorama test?

• The test is non-invasive, safe, risk-free for the course of pregnancy and poses no risk to your baby.
• The test provides information on the risk of your baby developing the diseases that the test examines.
• The test can be performed after the 9th week of pregnancy.
• The result of the test is available within 10 working days.
• The test finds most chromosomal defects. It is the only one to distinguish free extracellular fetal (placental) DNA from maternal DNA.
• The Panorama test is currently the best, that is, the most accurate test on the market. Thanks to the use of unique technology to distinguish between the DNA of the baby and the DNA of the mother, the results are reliable. Compared to other tests of this type, a lower rate of false results is achieved. The Panorama test detects the risk of more genetic variations than the PAPP-A test.

Panorama test - scope:

Panorama test: chromosomes 13, 18, 21, X and Y; triploidy, deletion of 22q11.2

DiGeorge syndrome is unavailable for twins and oocyte donor pregnancies. In the case of a twin pregnancy, the Panorama Test will determine with almost 100% certainty the sex of both fetuses.

In the case of a twin pregnancy, the basic test should be marked on the form.

Panorama test + DiGeorge syndrome - a test that assesses the risk of chromosomal anomalies.

Have doubts or questions? Use our hotline (22 566 22 22).

Prenatal testing - how to perform?

To perform the test, a referral and a patient consent form are needed. Both are issued and filled out by the doctor in charge of the pregnancy.

After purchasing the test, the patient with the completed documents goes to the blood draw during the collection center's working hours. You are welcome to come to the intake with an ID card or other document proving your identity.

Waiting time for the result is 10 working days. The results come in paper form and are picked up by the patient at the Result Dispensing Point. 

A consultation with a gynecologist is encouraged to discuss the result.